Stunnix (www.stunnix.com) has released Web4GUI, its tool for developers that allows them to produce apps out of PHP/Python/Java/MySQL websites.
The apps produced with Web4GUI can run directly from CDs/DVDs/USB drives or network shares. They look like usual desktop apps.
Web4GUI works with Mac OS X 10.4 or higher. Pricing starts at $239. A demo is available for download.