The Escapers has released Flux 2.0 (http://theescapers.com/flux2/), an update of the Mac OS X app that allows drag ‘n drop creation of web pages without the need of knowledge of XHTMLICSS (though you can twiddle with the code if you like).
Now users can work directly off FTP and SFTP sites, so there’s no need to repeatedly download and publish your site. But if publishing your site from your local computer suits your workflow, Flux can not only publish to FTP, SFTP, and MobileMe, but Flux can also compress all your images on the fly while publishing. This means that your large PNGs get compressed before they get uploaded.
Flux is Universal Binary so runs natively on both PowerPC and Intel Macs. It requires for Mac OS X 10.5 or higher. A 30-day demo is available at The Escapers web site. Registration is approximately US$70; version 2 is a free update for registered users.